In 1986, Gerd Binnig and Heinrich Rohrer won the Nobel Prize in Physics for the invention of the Scanning Tunneling Microscope (STM). It was a revolutionary way to imagine high-resolution microscopy, but it was limited to imaging conducting samples. Since then, the field evolved with the development of broader scanning probe microscope (SPM) technologies, the most promising being the atomic force microscope (AFM). AFM succeeded because it can achieve atomic resolution, measure topography, and probe other force-related material properties.
At present, AFM has surpassed its role as a high-resolution imaging tool to become the preferred technique to measure behavior at the nanoscale. Going beyond the initial idea of single-point analysis, it now details properties such as stiffness and adhesion, factors that directly affect material performance. Technical advancements have further made the technique more precise, accurate, and easier to use, paving the way for industrial and biological applications. The top AFM manufacturers in the market are scaling AFM for larger samples, workflow automation, and data analysis integrations. All these factors make AFM a practical tool in data-driven decision-making across semiconductors, energy materials, and healthcare.
These companies are contributing effectively to the global atomic force microscopy market, which, according to Kings Research, will reach USD 1,048.9 million by 2031, growing at a CAGR of 9.89% over the forecast period.
Top 10 AFM Manufacturers Driving Nanoscale Research
1. Park Systems
Park Systems is a leading provider of atomic force microscopy (AFM) solutions, renowned for its advanced nanometrology technologies. The company offers a wide range of AFM systems designed to meet the diverse needs of research and industrial applications, helping scientists and engineers push the boundaries of nanoscale research.
In 2021, Park Systems launched the Park FX40, an innovative autonomous AFM that incorporates advanced robotics and artificial intelligence. This groundbreaking AFM is designed to automate setup and scanning processes, significantly improving efficiency and accuracy in nanoscale research.
Building on the success of the FX40, the company launched new AI-driven metrology workflows in 2025. These workflows require minimal manual input for industrial wafer inspection. Their systems are now standard in South Korean and Taiwanese semiconductor hubs for high-throughput, non-destructive surface analysis.
2. Hitachi High-Tech Corporation
Hitachi High-Tech Corporation, a subsidiary of Hitachi Ltd., specializes in high-tech solutions, including electron and optical systems. Their portfolio includes advanced atomic force microscopes tailored for both research and industrial applications.
Hitachi High-Tech has enhanced its AFM offerings, like AFM500 Pro, with advanced software integration for improved imaging and data analysis. This innovation aims to increase the usability and precision of AFM technology in semiconductor and materials science research.
3. Nanonics Imaging Ltd
Nanonics Imaging Ltd is known for its innovative contributions to AFM and near-field scanning optical microscopy (NSOM). The company offers integrated solutions that combine AFM with other high-resolution imaging techniques.
4. Bruker
Bruker is a prominent name in scientific instruments, offering a comprehensive range of AFM systems. Bruker’s AFMs are widely used in various fields, including materials science, biology, and nanotechnology.
In January 2022, Bruker launched a cutting-edge BioAFM system designed to revolutionize the field of mechanobiology. This advanced atomic force microscopy (AFM) tool offers high-speed automated measurements, significantly enhancing the ability to study the mechanical properties of biological samples at the nanoscale.
5. Keysight Technologies
Keysight Technologies specializes in electronic measurement solutions and offers advanced AFM systems that integrate with its broader suite of electronic and optical measurement tools.
Keysight recently updated its AFM platform with enhanced imaging modes and a new control system that allows for faster and more precise measurements, catering to the needs of semiconductor and life science research.
6. Oxford Instruments
Oxford Instruments provides a range of high-tech tools for scientific research, including advanced AFM systems. They focus on delivering solutions that combine AFM with other analytical techniques for comprehensive material analysis.
The company has developed an advanced AFM system with enhanced resolution and sensitivity, specifically designed for applications in quantum materials and nanotechnology.
7. Nanosurf
Nanosurf is a key player in the AFM market, known for its compact and user-friendly AFM systems. Their instruments are widely used in both educational and research settings for nanotechnology and materials science.
In October 2025, Nanosurf launched WaveMode technology available on the DriveAFM and industrial Alphacen 300 Drive. This tech sets a new standard for measuring semiconductor surface roughness. WaveMode uses photothermal off-resonance excitation via CleanDrive. It delivers subnanometer roughness measurements up to 15 times faster than traditional dynamic mode. Tip stability remains consistent over 9 days of wafer measurements. This makes high-resolution AFM practical for high-volume cleanroom semiconductor manufacturing.
8. Horiba, Ltd.
Horiba, Ltd. is a diversified technology company that provides analytical and measurement instruments, including AFM systems. They are well-regarded for integrating AFM with Raman spectroscopy for comprehensive material analysis.
In 2023, Horiba introduced a new AFM-Raman hybrid system that offers high-resolution topographical imaging combined with detailed chemical analysis, targeting advanced research in materials science and nanotechnology.
9. NT-MDT Spectrum Instruments
NT-MDT Spectrum Instruments specializes in AFM technology, providing advanced tools for high-resolution imaging and surface analysis. Their products are used globally in scientific research and industrial applications.
NT-MDT unveiled a new AFM model featuring enhanced sensitivity and a broader range of operational modes, designed to meet the evolving needs of nanoscience research.
10. Semilab Inc.
Semilab Inc. is a leader in metrology solutions, offering specialized AFM systems for semiconductor manufacturing and material characterization. Their tools are designed to provide precise surface measurements and defect analysis.
In 2023, Semilab developed a next-generation AFM system that integrates optical and electrical measurement capabilities, aimed at providing comprehensive analysis solutions for semiconductor research and development.
Conclusion
Atomic force microscopy imaging stands out as a powerful and versatile tool that enables researchers to explore the nanoscale world with exceptional precision. Its ability to provide detailed topographical information and assess material properties under various conditions makes it invaluable across diverse fields, including materials science, biology, and nanotechnology.
As advancements in AFM technology continue to emerge, its applications will likely expand, driving further innovations and discoveries in understanding complex materials and biological systems.
