Gene Synthesis Market

Gene Synthesis Market Size

The global Gene Synthesis Market size was valued at USD 2245.5 million in 2023 and is projected to grow from USD 2736.81 million in 2024 to USD 12204.87 million by 2031, exhibiting a CAGR of 23.81% over the forecast period.

The rapid development of synthetic biology has significantly boosted the demand for gene synthesis technologies. The growing use of synthetic genes in medicine, agriculture, and industrial biotechnology is fueling market growth, with advanced gene synthesis methods enhancing precision and efficiency.

In the scope of work, the report includes services offered by companies such as Thermo Fisher Scientific, Inc., Twist Bioscience, Boster Biological Technology, Biomatik, OriGene Technologies, Inc., Azenta, Inc. (GENEWIZ), Merck KGaA, Evonetix, Integrated DNA Technologies, Inc., ProMab, and others.

The shift toward personalized medicine has led to a rise in demand for custom gene synthesis. The ability to tailor genetic material to individual patients for gene therapy and targeted treatments is accelerating investments in gene synthesis technologies, particularly for rare and genetic diseases.

Gene synthesis is a laboratory process that artificially constructs genes by assembling nucleotides in a specified sequence. This technology enables the design of DNA sequences de novo, without the need for an existing template.

It is widely used in molecular biology, synthetic biology, and biotechnology for applications such as creating custom genes, optimizing gene expression, producing recombinant proteins, and engineering genetic circuits. This method provides precise control over genetic material, enabling advancements in research, medicine, and industrial biotechnology.

Analyst’s Review

Continuous advancements in gene synthesis platforms are fueling the expansion of the gene synthesis market. Innovations such as automated DNA synthesis, error correction technologies, and high-throughput systems are improving the efficiency and precision of gene synthesis processes.

These technological improvements are significantly reducing turnaround times and production costs, enhancing accessibility across industries such as biotechnology, pharmaceuticals, agriculture, and synthetic biology.

• In August 2024, Integrated DNA Technologies (IDT), a global leader in genomics solutions, introduced Rapid Genes, a new addition to its synthetic biology portfolio designed to accelerate pharmaceutical research. These ready-to-use, next-generation sequencing (NGS)-verified clonal genes, ranging from 125 to 2000 base pairs (bp), are delivered in as little as five business days. Priced at USD 0.15 per bp and available in a plate format for automated workflows, Rapid Genes ensures faster turnaround times, consistent pricing, and reliable support offering researchers a comprehensive solution for efficient high-throughput screening and drug discovery.

Moreover, the integration of artificial intelligence and machine learning into design and optimization processes enhances capabilities, streamlines complex workflows, and delivers higher accuracy. These advancements are fostering adoption across diverse applications and attracting substantial investments, propelling market growth.

Gene Synthesis Market Growth Factors

The pressing need for biopharmaceuticals is driving the growth of the gene synthesis market. Pharmaceutical companies are utilizing gene synthesis technologies to produce recombinant proteins, enzymes, and monoclonal antibodies for therapeutic use. The increasing prevalence of chronic diseases and the demand for innovative treatments have fueled the need for these products.

• A report released by the World Health Organization in September 2023 emphasizes that noncommunicable diseases (NCDs) cause 41 million deaths annually, comprising 74% of global deaths. Cardiovascular diseases lead with 17.9 million fatalities, followed by cancers at 9.3 million, chronic respiratory diseases at 4.1 million, and diabetes-related kidney complications, accounting for 2 million deaths each year.

Gene synthesis offers precision and scalability in manufacturing these biopharmaceuticals, making it a crucial tool for meeting market demands and addressing healthcare challenges, thereby accelerating the adoption of gene synthesis technologies across the industry.

The increasing application of gene synthesis in agricultural biotechnology is fostering the growth of the gene synthesis market. Genetic engineering of crops to improve traits such as enhanced yield, pest resistance, and tolerance to environmental stress relies heavily on synthesized genes.

These innovations address the rising global demand for food security and sustainable agricultural practices. Gene synthesis allows researchers to design and introduce specific genetic modifications, accelerating the development of genetically modified organisms (GMOs).

However, the high cost associated with advanced technologies and custom gene synthesis services is hindering the growth of the market, particularly for small-scale laboratories and academic researchers with limited budgets. These costs can hinder the widespread adoption of gene synthesis, especially in emerging markets.

To address this challenge, companies are investing in cost-effective synthesis technologies, such as automated platforms and scalable production methods. Additionally, they are forming strategic partnerships and offering flexible pricing models, including tiered pricing and subscription-based services, to enhance accessibility. These measures are driving broader market penetration and adoption.

Gene Synthesis Industry Trends

The integration of CRISPR-based gene-editing technologies is emerging as a major trend reshaping the landscape of the gene synthesis market. CRISPR systems require precise guide RNA sequences and repair templates, which are efficiently generated using gene synthesis.

The widespread adoption of CRISPR in genetic research, therapeutic development, and agriculture is creating a robust demand for custom DNA synthesis. These advancements are driving research and commercial applications, further enhancing the role of gene synthesis in delivering innovative solutions.

The rising demand for molecular diagnostics is bolstering the growth of the gene synthesis market. Synthesized DNA sequences are integral to the creation of probes, primers, and other diagnostic tools used in PCR and other genetic testing techniques. These tools are essential for detecting genetic mutations, pathogens, and biomarkers associated with various diseases.

• In November 2024, TruDiagnostic introduced TruHealth, an at-home DNA testing solution designed to assess personalized nutrition and overall health. The test analyzes over 150 biomarkers, providing insights into vitamins, minerals, antioxidants, healthy fats, amino acids, and toxins. It also evaluates inflammation rates, oxidative stress, neurocognitive factors, and hormone levels, offering a comprehensive view of individual biological systems.

With the growing prevalence of personalized healthcare and early diagnostic practices, gene synthesis has become a pivotal technology for developing accurate and scalable diagnostic solutions. This trend is contributing significantly to the expansion of the market.

Segmentation Analysis

The global market has been segmented based on type, application, end-user, and geography.

By Type

Based on type, the market has been segmented into gene synthesis products and gene synthesis services. The gene synthesis services segment led the gene synthesis market in 2023, reaching a valuation of USD 1052.98 million.

These services, which can be tailored, enable researchers to obtain high-quality, error-free synthetic genes without the need for in-house expertise or resources. Their growing adoption in pharmaceutical and biotechnology companies is facilitated by their ability to streamline drug discovery, gene therapy development, and vaccine production.

Additionally, the increasing demand for custom gene synthesis services in synthetic biology applications, including metabolic engineering and agricultural biotechnology, has solidified its position. Its scalability, cost-efficiency, and rapid turnaround times further enhance its appeal, contributing to robust segmental growth.

By Application

Based on application, the market has been classified into gene editing, vaccine development, functional genomics, protein production, synthetic biology, academic and industrial research, and others. The gene editing segment secured the largest revenue share of 25.65% in 2023.

Gene synthesis is integral to creating customized DNA sequences for precise gene modifications, supporting technologies such as CRISPR-Cas9. This precision has accelerated applications in disease modeling, gene therapy, and drug discovery, where the demand for accurate and efficient gene editing tools continues to grow.

Furthermore, the increasing focus on developing genetically modified crops to address global food security challenges underscores the importance of gene editing.

By End-User

Based on end-user, the market has been divided into biopharmaceutical companies, academic and research institutes, contract research organizations (CROS), gene editing companies, and others. The gene editing companies segment is poised to witness significant growth, registering a robust CAGR of 25.55% through the forecast period, attributed to their extensive reliance on synthesized genes for precise genetic modifications and research.

These companies require custom gene sequences to develop cutting-edge tools such as CRISPR-Cas9, TALENs, and ZFNs, which are essential for applications ranging from therapeutic development to agricultural enhancements.

The demand is further supported by the need for large-scale, error-free gene libraries used in functional genomics studies and drug discovery. Moreover, gene editing firms prioritize high-throughput synthesis platforms to streamline workflows, reduce turnaround times, and enhance scalability, aiding the growth of the end-user segment.

Gene Synthesis Market Regional Analysis

Based on region, the global market has been classified into North America, Europe, Asia Pacific, Middle East & Africa, and Latin America.

The North America gene synthesis market accounted for a substantial share of around 38.92% in 2023, with a valuation of USD 873.86 million. North America, particularly the U.S., boasts a well-established R&D ecosystem with numerous leading biotechnology and pharmaceutical companies, as well as academic and research institutions.

This strong infrastructure facilitates extensive research activities in synthetic biology, genomics, and personalized medicine, thereby increasing the demand for gene synthesis services. The presence of major market players and continuous investment in R&D further contribute to the regional market expansion.

• In November 2024, the Center for Health Security unveiled the Gene Synthesis Screening Information Hub, an online platform designed to assist nucleic acid synthesis providers, manufacturers, and customers comply with a new federal Framework. This initiative aims to prevent the misuse of synthetic nucleic acids while promoting safe and ethical scientific research practices across the United States.

The strong presence of companies, including Thermo Fisher Scientific Inc., Twist Bioscience Corporation, and Integrated DNA Technologies, Inc., along with their continuous efforts in research, development, and commercialization of gene synthesis products and services, significantly supports regional market growth.

Asia Pacific gene synthesis market is set to witness significant growth, recording a staggering CAGR of 25.07% over the forecast period. The increasing incidence of genetic disorders and chronic diseases in the region has highlighted the need for advanced diagnostic and therapeutic solutions. Gene synthesis plays a crucial role in developing targeted treatments and personalized medicine approaches, boosting its adoption in healthcare settings.

• In May 2024, iMeUsWe launched its DNA testing services in collaboration with MapMyGenome. These services deliver comprehensive insights into health, wellness, and ancestry, along with expert genetic counseling. This complimentary service offers personalized guidance tailored to individual goals, lifestyle choices, family health history, and genetic findings.

Agriculture plays a crucial role in economic development, and genetic modification technologies are viewed as a key to boosting crop yield and resilience in Asia Pacific. Gene synthesis is being increasingly used to engineer crops with improved traits such as pest resistance, enhanced nutritional value, and drought tolerance.

Countries such as China and India have invested heavily in agricultural biotechnology, promoting the use of gene synthesis in developing genetically modified (GM) crops.

Competitive Landscape

The global gene synthesis market report will provide valuable insight with an emphasis on the fragmented nature of the industry. Prominent players are focusing on several key business strategies such as partnerships, mergers and acquisitions, product innovations, and joint ventures to expand their product portfolio and increase their market shares across different regions.

Strategic initiatives, including investments in R&D activities, the establishment of new manufacturing facilities, and supply chain optimization, could create new opportunities for market growth.

List of Key Companies in Gene Synthesis Market

• Thermo Fisher Scientific, Inc.
• Twist Bioscience
• Boster Biological Technology
• Biomatik
• OriGene Technologies, Inc.
• Azenta, Inc. (GENEWIZ)
• Merck KGaA
• Evonetix 
• Integrated DNA Technologies, Inc.
• ProMab

Key Industry Developments

• May 2024 (Launch): Twist Bioscience Corporation launched its new Twist Multiplexed Gene Fragments (MGFs), which are pools of directly synthesized double-stranded DNA (dsDNA) up to 500 base pairs in length. These gene fragments, with no sequence number limitations, are designed for high-throughput screening applications.
• October 2023 (Launch): Evonetix announced the installation of its first DNA synthesis development platform at Imperial College London for evaluation. This marks the company's first deployment of its platform in an external scientific environment, a key step in advancing its gene synthesis technology toward customer adoption and commercialization.

The global gene synthesis market has been segmented as:

By Type

• Gene Synthesis Products
• Gene Synthesis Services

By Application

• Gene Editing
• Vaccine Development
• Functional Genomics
• Protein Production
• Synthetic Biology
• Academic and Industrial Research
• Others

By End-User

• Biopharmaceutical Companies
• Academic and Research Institutes
• Contract Research Organizations (CROs)
• Gene Editing Companies
• Other

By Region

• North America
  • U.S.
  • Canada
  • Mexico
• Europe
  • France
  • UK
  • Spain
  • Germany
  • Italy
  • Russia
  • Rest of Europe
• Asia-Pacific
  • China
  • Japan
  • India
  • South Korea
  • Rest of Asia-Pacific
• Middle East & Africa
  • GCC
  • North Africa
  • South Africa
  • Rest of Middle East & Africa
• Latin America
  • Brazil
  • Argentina
  • Rest of Latin America